Second-generation total synthesis of (-)-diversifolin

被引：8

作者：

Tsuboi, Kazuma ^{[1
]}

Nakamura, Tomoaki ^{[1
]}

Suzuki, Takahiro ^{[1
]}

Nakazaki, Atsuo ^{[1
]}

Kobayashi, Susumu ^{[1
]}

机构：

[1] Tokyo Univ Sci RIKADAI, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 14期

基金：

日本学术振兴会;

关键词：

NF-KAPPA-B; RING-CLOSING METATHESIS; SESQUITERPENE LACTONES; OLEFIN METATHESIS; ALDEHYDES; INHIBITION; COMPLEXES; LIGANDS; ETHERS; ESTERS;

D O I：

10.1016/j.tetlet.2010.02.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A second-generation total synthesis of (-)-diversifolin has been achieved by a more straightforward strategy. involving a highly stereochemistry-dependent 10-membered ring-closing metathesis and a stereoselective dihydroxylation/lactone transposition sequence. Compared to Our previous synthesis, the present synthesis is improved in the yield of the key intermediate 2 (20% in 12 steps from diol 8). (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1876 / 1879

页数：4

共 50 条

[21] Total synthesis of (-)-virginiamycin M(2) using second-generation vinylogous urethane chemistry
Schlessinger, RH
Li, YJ
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (13) : 3301 - 3302
[22] Sustainable Biocatalytic Synthesis of a Second-Generation Biolubricant
Montiel, Maria Claudia
Gomez, Maria
Murcia, Maria Dolores
Ortega-Requena, Salvadora
Maximo, Fuensanta
Bastida, Josefa
SUSTAINABILITY, 2024, 16 (04)
[23] Second-generation pterocarpanquinones: synthesis and antileishmanial activity
Faioes, Viviane dos Santos
da Frota, Livia C. R. M.
Cunha-Junior, Edezio Ferreira
Barcellos, Julio C. F.
Da Silva, Thayssa
Netto, Chaquip Daher
Goncalves Da-Silva, Silvia Amaral
da Silva, Alcides J. M.
Costa, Paulo R. R.
Torres-Santos, Eduardo Caio
JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, 2018, 24
[24] Total synthesis of (-)-kainic acid via intramolecular Michael addition: A. Second-generation route
Sakaguchi, Hiroshi
Tokuyama, Hidetoshi
Fukuyama, Tohru
ORGANIC LETTERS, 2008, 10 (09) : 1711 - 1714
[25] Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions
Hayakawa, Ichiro
Saito, Keita
Matsumoto, Sachiko
Kobayashi, Shinichi
Taniguchi, Ayaka
Kobayashi, Kenichi
Fujii, Yusuke
Kaneko, Takahiro
Kigoshi, Hideo
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 15 (01) : 124 - 131
[26] Synthesis and characterization of second-generation dialkylphenacylsulfonium salt photoinitiators
Crivello, JV
Kong, SQ
MACROMOLECULES, 2000, 33 (03) : 825 - 832
[27] Second-Generation Synthesis of (+)-Fastigiatine Inspired by Conformational Studies
DeForest, Jacob C.
Samame, Renzo A.
Suryn, Gregory
Burtea, Alexander
Rychnovsky, Scott D.
JOURNAL OF ORGANIC CHEMISTRY, 2018, 83 (16): : 8914 - 8925
[28] A Second-Generation Synthesis of the Cyanthiwigin Natural Product Core
Kim, Kelly E.
Stoltz, Brian M.
ORGANIC LETTERS, 2016, 18 (21) : 5720 - 5723
[29] ORGN 691-A second-generation synthesis of Leucascandrolide A
Van Orden, Lori Jean
Patterson, Brian D.
Rychnovsky, Scott D.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
[30] Second-generation biopharmaceuticals
Walsh, G
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 58 (02) : 185 - 196

← 1 2 3 4 5 →