Second-generation total synthesis of (-)-diversifolin

被引：8

作者：

Tsuboi, Kazuma ^{[1
]}

Nakamura, Tomoaki ^{[1
]}

Suzuki, Takahiro ^{[1
]}

Nakazaki, Atsuo ^{[1
]}

Kobayashi, Susumu ^{[1
]}

机构：

[1] Tokyo Univ Sci RIKADAI, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 14期

基金：

日本学术振兴会;

关键词：

NF-KAPPA-B; RING-CLOSING METATHESIS; SESQUITERPENE LACTONES; OLEFIN METATHESIS; ALDEHYDES; INHIBITION; COMPLEXES; LIGANDS; ETHERS; ESTERS;

D O I：

10.1016/j.tetlet.2010.02.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A second-generation total synthesis of (-)-diversifolin has been achieved by a more straightforward strategy. involving a highly stereochemistry-dependent 10-membered ring-closing metathesis and a stereoselective dihydroxylation/lactone transposition sequence. Compared to Our previous synthesis, the present synthesis is improved in the yield of the key intermediate 2 (20% in 12 steps from diol 8). (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1876 / 1879

页数：4

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