A Study on single-dose oral toxicity of D-allose in ICR mice

被引：0

作者：

Choi, Mi Na ^{[1
]}

Kim, Yeong-Su ^{[1
]}

Lee, Hwan ^{[2
]}

Shin, Kyung-Chul ^{[3
]}

机构：

[1] Baekdudaegan Natl Arboretum, Forest Bioresources Dept, Bonghwa 36209, South Korea

[2] Healthbalance Corp, Res Inst, Seoul 06164, South Korea

[3] Konkuk Univ, Dept Integrat Biosci & Biotechnol, Seoul 05029, South Korea

来源：

MAEJO INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY | 2022年 / 16卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

D-allose; single-dose oral toxicity; ICR mice; SUBCHRONIC TOXICITY; CARCINOMA CELLS; SUGAR; SWEETENERS; PROTECTS; GROWTH; HEXOSE;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

D-Allose is a rare natural sugar, which is attractive as a sweetener alternative to sugar because of its biological functions and low-calorie content. However, there is a lack of basic information regarding the use of D-allose as a food ingredient. In this study D-allose toxicity to ICR mice was investigated. The mice were treated with a single dose of D-allose (1,250, 2,500 or 5,000 mg/kg body weight). No organ injury was observed, nor any changes observed in the clinical sign, body weight and the blood serum chemistry. The approximate lethal dose was estimated to exceed 5,000 mg/kg in mice. These results suggest that D-allose is practically non-toxic to mice.

引用

页码：170 / 178

页数：9

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