Conjugate addition of amino acid side chains to alkynones and alkynoic acid derivatives

被引：33
|
作者：
Crisp, GT [1 ]
Millan, MJ [1 ]
机构：
[1] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia
来源：
TETRAHEDRON | 1998年 / 54卷 / 3-4期
关键词：
D O I：
10.1016/S0040-4020(97)10323-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Suitably protected amino acids were used to investigate the Michael addition of the sulfanyl group of cysteine, the hydroxyl group of serine and the epsilon-amino group of lysine to a conjugated alkynone, alkynoic ester and alkynoic amide. The expected heterosubstituted vinyl product was formed in each case. (C) 1997 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：637 / 648
页数：12
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