Immune cell profiling in the cerebrospinal fluid of patients with primary angiitis of the central nervous system reflects the heterogeneity of the disease

被引:15
|
作者
Strunk, Daniel [1 ]
Schulte-Mecklenbeck, Andreas [1 ]
Golombeck, Kristin S. [1 ]
zu Hoerste, Gerd Meyer [1 ]
Melzer, Nico [1 ]
Beuker, Carolin [1 ]
Schmidt, Antje [1 ]
Wiendl, Heinz [1 ]
Meuth, Sven G. [1 ]
Gross, Catharina C. [1 ]
Minnerup, Jens [1 ]
机构
[1] Univ Munster, Univ Hosp Munster, Clin Neurol, Inst Translat Neurol, D-48149 Munster, Germany
关键词
Cerebrospinal fluid; Flow cytometry; PACNS; CEREBRAL AMYLOID ANGIOPATHY; BETA-RELATED ANGIITIS; GRANULOMATOUS-ANGIITIS; TAKAYASUS-ARTERITIS; NK CELLS; EXPRESSION; TISSUE; BLOOD;
D O I
10.1016/j.jneuroim.2018.06.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patients with multiple sclerosis, ischemic stroke, and somatoform disorders (n = 18 per group). Changes in the intrathecal immune-cell profile were heterogeneous in PACNS. While proportions of T-cell subsets remained unaltered, some PACNS patients showed a shift toward NK- or B cells. Intrathecal immunoglobulin synthesis was observed in a subgroup of PACNS patients with an increased frequency of antibody producing plasma cells.
引用
收藏
页码:109 / 116
页数:8
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