Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas

被引：1
|
作者：
He, Yi-Lin [1 ,2 ]
Huang, Pei-Zhi [1 ]
Yang, Hong-Ying [1 ]
Feng, Wei-Jiao [1 ]
Li, Zhao-Cai [3 ]
Gao, Kun [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Lanzhou Jiaotong Univ, Sch Biol & Pharmaceut Engn, Res Inst, Lanzhou 730070, Peoples R China
[3] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Lanzhou 730046, Peoples R China
来源：
MOLECULES | 2022年 / 27卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Euphorbiaceae; Jatropha curcas L; neolignan; jatrolignans; epimers; antichlamydial activity; DIASTEREOMERS; BARK;
D O I：
10.3390/molecules27113540
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new neolignans jatrolignans, C (1) and D (2), a pair of epimers, were isolated from the whole plants of Jatropha curcas L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in Chlamydia abortus. They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 mu M.
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页数：9
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