Viral Vaccines and CTL Response

被引:20
|
作者
Woolard, Stacie N. [1 ]
Kumaraguru, Uday [1 ]
机构
[1] E Tennessee State Univ, Quillen Dishner Coll Med, Dept Microbiol, Johnson City, TN 37614 USA
关键词
HEPATITIS-C VIRUS; CD8; T-CELLS; IMMUNE-RESPONSES; HUMORAL IMMUNITY; DENDRITIC CELLS; WEST-NILE; MEMORY; INFECTION; CANCER; IL-15;
D O I
10.1155/2010/141657
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T cells, which principally function to control and eradicate intracellular pathogens, is enabled by constitutive expression of MHC class-I molecules on all tissue types. CTL induction offers hope for vaccines against pathogens that are resistant to neutralizing activity. This review discusses the mechanism of immune induction by some successful vaccines and based on the accrued evidence suggests ideas for improved design of CTL-inducing vaccines.
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页数:6
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