Clonal spread of mef-positive macrolide-resistant Streptococcus pneumoniae isolates causing invasive disease in adults in Germany

被引：14
|
作者：
van der Linden, Mark [1 ]
Al-Lahham, Adnan [1 ]
Haupts, Stefan [1 ]
Reinert, Ralf Rene [1 ]
机构：
[1] Univ Hosp RWTH, Inst Med Microbiol, Natl Reference Ctr Streptococci, Aachen, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 05期
关键词：
D O I：
10.1128/AAC.01453-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Isolates (3,845) obtained from German adults with invasive pneumococcal disease between 1992 and 2004 were investigated. Of these, 430 isolates (11.2%) were erythromycin A nonsusceptible. Macrolide resistance genotypes and multilocus sequence types were determined. Among the isolates, 35.6% were erm(B) positive and 63.5% were mef positive. Over the study period, the frequency of resistance rose significantly from 2.2 to 17.0% (P < 0.001). A serotype 14, sequence type 9 clone was the most widespread.
引用
收藏
页码：1830 / 1834
页数：5
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