Lipid Droplet Metabolism during Dengue Virus Infection

被引：38
|
作者：
Randall, Glenn [1 ]
机构：
[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA
来源：
TRENDS IN MICROBIOLOGY | 2018年 / 26卷 / 08期
关键词：
AUTOPHAGY;
D O I：
10.1016/j.tim.2018.05.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dengue virus (DENV) induces a proviral selective autophagy targeting lipid droplets, termed lipophagy, that stimulates lipid metabolism. Zhang et al. gained mechanistic insight into this process, demonstrating that DENV NS4A/B binds unmodified AUP1 and promotes its translocation from lipid droplets to autophagosomes to drive the induction of lipophagy.
引用
收藏
页码：640 / 642
页数：4
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