Electrophilic amination of ketone enolates mediated by the DiTOX asymmetric building block:: Enantioselective formal synthesis of α-aminoacids

被引：0

作者：

Page, PCB ^{[1
]}

McKenzie, MJ

Allin, SM

Buckle, DR

机构：

[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] SmithKline Beecham Pharmaceut, Epsom KT18 5XQ, Surrey, England

来源：

TETRAHEDRON | 2000年 / 56卷 / 49期

关键词：

asymmetric synthesis; aminoacid; chiral auxiliary; enolate;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoselective electrophilic amination of enolates derived from 2-acyl-1,3-dithiane 1-oxides is used as the key step for an enantioselective synthesis of two alpha -hydrazido carboxylic acids, well-known precursors of alpha -amino acids. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9683 / 9695

页数：13