Electrophilic amination of ketone enolates mediated by the DiTOX asymmetric building block:: Enantioselective formal synthesis of α-aminoacids

被引：0
|
作者：
Page, PCB [1 ]
McKenzie, MJ
Allin, SM
Buckle, DR
机构：
[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England
[2] SmithKline Beecham Pharmaceut, Epsom KT18 5XQ, Surrey, England
来源：
TETRAHEDRON | 2000年 / 56卷 / 49期
关键词：
asymmetric synthesis; aminoacid; chiral auxiliary; enolate;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diastereoselective electrophilic amination of enolates derived from 2-acyl-1,3-dithiane 1-oxides is used as the key step for an enantioselective synthesis of two alpha -hydrazido carboxylic acids, well-known precursors of alpha -amino acids. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：9683 / 9695
页数：13
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