Review: Placental adaptations to the presence of maternal asthma during pregnancy

被引：31

作者：

Meakin, A. S. ^{[1
]}

Saif, Z. ^{[1
]}

Jones, A. R. ^{[1
]}

Aviles, P. F. Valenzula ^{[1
]}

Clifton, V. L. ^{[1
]}

机构：

[1] Univ Queensland, Mater Med Res Inst, Brisbane, Qld, Australia

来源：

PLACENTA | 2017年 / 54卷

关键词：

Placenta; Asthma; Fetus; Sex; Growth; GLUCOCORTICOID-RECEPTOR ISOFORMS; ANTIOXIDANT ENZYME-ACTIVITY; GENE-EXPRESSION; FETAL SEX; BIOLOGICAL OXIDATION; PERINATAL OUTCOMES; GROWTH RESTRICTION; CANCER CELLS; CORTISOL; TESTOSTERONE;

D O I：

10.1016/j.placenta.2017.01.123

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Asthma is a highly prevalent chronic medical condition affecting an estimated 12% of pregnant, women each year, with prevalence of asthma greatest (up to 16%) among the socially disadvantaged. Maternal asthma is associated with significant perinatal morbidity and mortality including preterm births, neonatal hospitalisations and low birthweight outcomes each year. We have identified that the placenta adapts to the presence of chronic, maternal asthma during pregnancy in a sex specific manner that may confer sex differences in fetal outcome. The male fetus was at greater risk of a poor outcome than a female fetus in the presence of maternal asthma and an acute inflammatory event such as an asthma exacerbation. This review will examine the role of sex specific differences in placental function on fetal growth and survival. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：17 / 23

页数：7

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