Risk of preterm birth and low birthweight following consecutive surgical and medical abortions

To examine the effect of consecutive surgical compared to medical uterine evacuations on spontaneous preterm birth (SPTB) and low birthweight (LBW) rates in the immediate subsequent delivery. Retrospective study, conducted at a teaching hospital on data from January 2000 to March 2016. First study group consisted of all women who had ae<yen>2 consecutive medical evacuations (ME-Group); second study group consisted of women who had ae<yen>2 consecutive surgical evacuations (SE-Group). Both had a subsequent singleton delivery. Control group consisted of women without previous evacuations (unexposed group). The groups were matched for year of birth and ethnicity. The primary outcome was a composite that included SPTB (< 37 weeks) and LBW (< 2500 g). All 70 women found eligible in the ME-Group during the study period were included. SE-Group and the unexposed group consisted of 140 and 210 women, respectively. Primary outcome occurred in 4.3, 11.4, and 2.4% in the ME-Group, SE-Group, and the unexposed group, respectively (p = 0.002). After adjusting for variables that differed between the groups in univariate analysis, the primary outcome incidence was significantly higher among the SE-Group compared to the unexposed group (adjusted OR 6.8, 95% CI 1.7-26.3, p = 0.006). The difference was insignificant between the ME-Group and the unexposed group (adjusted p = 0.31). In the SE-Group, 7.1% women required fertility treatments to achieve a desired pregnancy compared to 1.4% in the ME-Group (p = 0.04). Two or more consecutive surgical evacuations were associated with an increased risk of both SPTB and LBW compared to unexposed group.