Vincristine-induced Peripheral Neuropathy in a Neonate With Congenital Acute Lymphoblastic Leukemia

被引：6

作者：

Baker, Steven K. ^{[1
]}

Lipson, David M. ^{[1
]}

机构：

[1] McMaster Univ, Dept Med, Med Ctr, Neuromuscular Dis Clin, Hamilton, ON L8N 3Z5, Canada

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2010年 / 32卷 / 03期

关键词：

vincristine; neuropathy; neonate; neurotoxicity; GUILLAIN-BARRE-SYNDROME; ACETYL-L-CARNITINE; MARIE-TOOTH DISEASE; N-ACETYLCYSTEINE; NERVE; CELLS; NEUROTOXICITY; REGENERATION; CHEMOTHERAPY; PREVENTION;

D O I：

10.1097/MPH.0b013e3181d419ad

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of a 46-day-old boy with a fulminant vincristine-induced peripheral neuropathy after treatment for congenital acute lymphoblastic leukemia. Flaccid paralysis developed at the end of the first phase of induction, requiring intubation and ventilation for 51 days. Treatment was initiated with levocarnitine, N-acetylcysteine, and pyridoxine and progressive reversal of the neuropathy occurred over the next 4 months. Potential differences in pathogenesis and presentation of vincristine neurotoxicity and Guillian-Barre syndrome in the neonate are discussed.

引用

页码：E114 / E117

页数：4

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