The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification

被引：5
|
作者：
Tharp, Jeffery M. [1 ]
Liu, Wenshe R. [1 ]
机构：
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA
来源：
CHEMBIOCHEM | 2016年 / 17卷 / 10期
基金：
美国国家科学基金会;
关键词：
cysteine; pi clamp; protein modification; site selectivity; CYSTEINE; CHEMISTRY; ANTIBODY;
D O I：
10.1002/cbic.201600106
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pentelute and co-workers have identified a small encodable cysteine-containing peptide sequence that allows selective modification with perfluoroaryl probes. This π-clamp requires no external catalyst and is not limited to certain positions within a protein. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：883 / 885
页数：3
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