Role of melanin in the pathogenesis of cutaneous sporotrichosis

被引：33

作者：

Madrid, Isabel Martins ^{[1
]}

Xavier, Melissa O. ^{[1
,2
]}

Mattei, Antonella S. ^{[1
]}

Fernandes, Cristina G. ^{[3
]}

Guim, Thomaz N. ^{[3
]}

Santin, Rosema ^{[1
,4
]}

Schuch, Luiz Filipe D. ^{[1
]}

Nobre, Marcia de Oliveira ^{[1
,5
]}

Araujo Meireles, Mario Carlos ^{[1
]}

机构：

[1] Univ Fed Pelotas, Fac Vet, Dept Vet Prevent, BR-96010900 Pelotas, RS, Brazil

[2] Fundacao Univ Fed Rio Grande, Fac Med, Lab Micol, Rio Grande, RS, Brazil

[3] Univ Fed Pelotas, Fac Vet, Dept Patol Anim, BR-96010900 Pelotas, RS, Brazil

[4] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Vet, BR-90046900 Porto Alegre, RS, Brazil

[5] Univ Fed Pelotas, Fac Vet, Dept Clin Vet, BR-96010900 Pelotas, RS, Brazil

来源：

MICROBES AND INFECTION | 2010年 / 12卷 / 02期

关键词：

Sporothrix schenckii; Melanin; Virulence factors; SPOROTHRIX-SCHENCKII; NITRIC-OXIDE; CRYPTOCOCCUS-NEOFORMANS; INFECTION; VIRULENCE; CELLS; MICE; MELANIZATION; INVOLVEMENT;

D O I：

10.1016/j.micinf.2009.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we evaluate the clinical, histopathological and ultra structural aspects of the infection by field strain (MEL+) and mutated strain (MEL-) of Sporothrix schenckii. The development of sporotrichosis at the inoculation sites was similar for both groups of animals after the second week of the experimental period. Statistical differences appeared only at weeks 3 and 5. The pigmented isolate had greater tissue invasive capacity, promoting the formation of multifocal granulomas, whereas the albino isolate induced an enhanced inflammatory response, restraining the agent to the core of the granulomas. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：162 / 165

页数：4

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