Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression

被引：8

作者：

Hitora, Yuki ^{[1
,5
]}

Takada, Kentaro ^{[1
]}

Ise, Yuji ^{[2
,6
]}

Woo, Sau Pinn ^{[3
]}

Inoue, Seiya ^{[4
]}

Mori, Naoki ^{[4
,7
]}

Takikawa, Hirosato ^{[4
]}

Nakamukai, Shohei ^{[1
]}

Okada, Shigeru ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] Nagoya Univ, Grad Sch Sci, Sugashima Marine Biol Lab, Sugashima Cho, Toba, Mie 5170004, Japan

[3] Univ Sains Malaysia, Ctr Marine & Coastal Studies, Usm 11800, Penang, Malaysia

[4] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bukyo Ku, Tokyo 1138657, Japan

[5] Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto 8620973, Japan

[6] Univ Sains Malaysia, Ctr Marine & Coastal Studies, Gelugo, Penang, Malaysia

[7] Res Fdn ITSUU Lab, Takatsu Ku, 3-2-1 Sakado, Kawasaki, Kanagawa 2130012, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2020年 / 28卷 / 02期

关键词：

Terpenoid; Marine sponge; Cell-cycle; Structure elucidation; ABSOLUTE-CONFIGURATION; CHIROPTICAL PROPERTIES; CIRCULAR-DICHROISM; SESQUITERPENOIDS; PORIFERA; DICTYOCERATIDA; DEMOSPONGIAE; REPLICATION; QUINONES; CDT1;

D O I：

10.1016/j.bmc.2019.115233

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.

引用

页数：6

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