JAK Inhibitors for Treatment of Alopecia Areata

被引：53

作者：

Wang, Eddy H. C. ^{[1
]}

Sallee, Brigitte N. ^{[1
]}

Tejeda, Christina I. ^{[3
]}

Christiano, Angela M. ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Dermatol, 1150 St Nicholas Ave,Room 3038, New York, NY 10032 USA

[2] Columbia Univ, Genet & Dev, 1150 St Nicholas Ave,Room 3038, New York, NY 10032 USA

[3] Columbia Univ, Columbia Coll Phys & Surg, 1150 St Nicholas Ave,Room 3038, New York, NY 10032 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2018年 / 138卷 / 09期

关键词：

COMORBIDITY PROFILES; TOFACITINIB; RUXOLITINIB; PATIENT; UNIVERSALIS; REVERSAL; VARIANTS; VITILIGO; ONSET;

D O I：

10.1016/j.jid.2018.05.027

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The advancement of genetic and preclinical studies has uncovered the mechanisms involved in the pathogenesis of alopecia areata (AA). The development of targeted therapies using small molecules blocking specific pathways for the treatment of AA is underway. By repurposing Food and Drug Administration-approved small molecule JAK inhibitors as treatments for AA, it has been demonstrated that JAK inhibitors can effectively reverse hair loss in patients with moderate to severe AA. In this review, we summarize and discuss the current preclinical and clinical studies on JAK inhibitors, as well as the prospects of using JAK inhibitors for the treatment of AA.

引用

页码：1911 / 1916

页数：6

共 50 条

[41] Janus kinase inhibitors for the treatment of alopecia areata: a retrospective study
Dhonncha, E. Nic
Murphy, M.
Ryan, C.
Bourke, J.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2020, 183 : 89 - 89
[42] TREATMENT OF ALOPECIA AREATA
MEIGEL, WN
[J]. MEDIZINISCHE KLINIK, 1976, 71 (21): : 928 - 928
[43] Use of JAK Inhibitors in Patients with Alopecia areata at the Dermatology Clinic of the University Hospital in Erlange, Germany
Busch, Dorothee
Sticherling, Michael
[J]. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2023, 21 : 132 - 132
[44] Recalcitrant alopecia areata responsive to leflunomide and anthralin-Potentially undiscovered JAK/STAT inhibitors?
Sardana, Kabir
Gupta, Aastha
Gautam, Ram K.
[J]. PEDIATRIC DERMATOLOGY, 2018, 35 (06) : 856 - 858
[45] Management of alopecia areata in JAK-inhibitors era: are systemic and topical corticosteroids still useful?
Licata, Gaetano
Tancredi, Vittorio
Calabrese, Giulia
Buononato, Dario
De Rosa, Alina
Argenziano, Giuseppe
Gambardella, Alessio
[J]. INTERNATIONAL JOURNAL OF DERMATOLOGY, 2023, 62 (04) : E234 - E236
[46] Analysis of patient experiences regarding JAK inhibitors for atopic dermatitis, psoriasis, alopecia areata, and vitiligo
Sharma, Divya
Gart, Sophie
Kitrell, Bo
Lonowski, Sarah
Arthur, Megan
Wei, Erin X.
[J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2024, 316 (09)
[47] Janus kinase inhibitors for alopecia areata
King, Brett A.
Craiglow, Brittany G.
[J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2023, 89 (02) : S29 - S32
[48] The role of Janus kinase inhibitors in the treatment of alopecia areata: A systematic review
de Oliveira, Ana B.
Alpalhao, Miguel
Filipe, Paulo
Maia-Silva, Joao
[J]. DERMATOLOGIC THERAPY, 2019, 32 (05)
[49] Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib—A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata
Kinga Kołcz
Magdalena Żychowska
Edyta Sawińska
Adam Reich
[J]. Dermatology and Therapy, 2023, 13 : 843 - 856
[50] Alopecia Areata New Treatment Options Including Janus Kinase Inhibitors
Zheng, Caiwei
Tosti, Antonella
[J]. DERMATOLOGIC CLINICS, 2021, 39 (03) : 407 - 415

← 1 2 3 4 5 →