Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection

被引：85

作者：

Huang, Chun-Hao ^{[1
]}

Lee, Ko-Chuan ^{[1
]}

Doudna, Jennifer A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[4] Lawrence Berkeley Natl Lab, MBIB Div, Berkeley, CA 94720 USA

[5] Univ Calif Berkeley, Innovat Genom Inst, Berkeley, CA 94720 USA

来源：

TRENDS IN CANCER | 2018年 / 4卷 / 07期

关键词：

NUCLEIC-ACID DETECTION; OFF-TARGET CLEAVAGE; GUIDE-RNA; GENOMIC DNA; IN-VITRO; DELIVERY; CELLS; ACTIVATION; DISCOVERY; VERSATILE;

D O I：

10.1016/j.trecan.2018.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a complex disease caused by combinations of cellular genetic alterations and heterogeneous microenvironments. The use of the robust and programmable CRISPR-Cas systems has greatly improved genome editing for precision cancer modeling and enabled multiplexed genetic manipulation for cancer treatment and mutation detection. In this review, we outline the current CRISPR-Cas toolkit, and discuss the promises and hurdles in translating this revolutionary technology into effective and safe clinical applications for cancer treatment and diagnosis.

引用

页码：499 / 512

页数：14

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