Regulation of osteogenic differentiation by the pro-inflammatory cytokines IL-1β and TNF-α: current conclusions and controversies

被引：25
|
作者：
Mo, Qingyun [1 ]
Zhang, Wei [1 ,2 ,3 ]
Zhu, Aijing [1 ]
Backman, Ludvig J. [4 ,5 ]
Chen, Jialin [1 ,2 ,3 ]
机构：
[1] Southeast Univ, Sch Med, Nanjing 210009, Peoples R China
[2] Southeast Univ, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Peoples R China
[3] China Orthoped Regenerat Med Grp CORMed, Hangzhou, Peoples R China
[4] Umea Univ, Dept Integrat Med Biol, Anat, SE-90187 Umea, Sweden
[5] Umea Univ, Dept Community Med & Rehabil, Physiotherapy, SE-90187 Umea, Sweden
来源：
HUMAN CELL | 2022年 / 35卷 / 04期
基金：
中国国家自然科学基金;
关键词：
TNF-alpha; IL-1; beta; Osteogenesis; Species differences; MESENCHYMAL STEM-CELLS; NECROSIS-FACTOR-ALPHA; BONE-MARROW; MSCS; INTERLEUKIN-1-BETA;
D O I：
10.1007/s13577-022-00711-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Treatment of complex bone fracture diseases is still a complicated problem that is urged to be solved in orthopedics. In bone tissue engineering, the use of mesenchymal stromal/stem cells (MSCs) for tissue repair brings hope to the medical field of bone diseases. MSCs can differentiate into osteoblasts and promote bone regeneration. An increasing number of studies show that the inflammatory microenvironment affects the osteogenic differentiation of MSCs. It is shown that TNF-alpha and IL-1 beta play different roles in the osteogenic differentiation of MSCs via different signal pathways. The main factors that affect the role of TNF-alpha and IL-1 beta in osteogenic differentiation of MSCs include concentration and the source of stem cells (different species and different tissues). This review in-depth analyzes the roles of pro-inflammatory cytokines in the osteogenic differentiation of MSCs and reveals some current controversies to provide a reference of comprehensively understanding.
引用
收藏
页码：957 / 971
页数：15
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