Rapid synthesis of s-triazolo[3,4-b][1,3,4]thiadiazoles and quinolines under microwave irradiation

Several 3-alkyl/aryl-6-(2-chloro-2-substitutedphenylethenyl)-5,6-dihydro-s-triazolo [3,4-b] [1,3,4] thiadiazoles (IV) and 6-substituted-2-chloro-3-(3-alkyl/aryl-5,6-dihydro-s-triazolo [1,3,4] thiadiazol-6-yl) quinolines (V) have been synthesised by the condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazoles (I) with beta-chlorocinnamaldehydes (II), 6-substituted-2-chloro-3-formylquinolines (III) in unsealed vessels in a unmodified domestic microwave oven. Remarkable rate enhancement and dramatic reduction in reaction times have been observed with better yields.