RNA-Binding Motif Protein 11 (RBM11) Serves as a Prognostic Biomarker and Promotes Ovarian Cancer Progression

被引：9
|
作者：
Fu, Chunhong [1 ]
Yuan, Ming [2 ]
Sun, Jie [3 ]
Liu, Gang [2 ]
Zhao, Xiaojuan [2 ]
Chang, Wei [2 ]
Ma, Zhongling [2 ]
机构：
[1] Inner Mongolia Peoples Hosp, Dept Obstet & Gynecol, Hohhot 010017, Inner Mongolia, Peoples R China
[2] Xi An Jiao Tong Univ, Dept Oncol, Changan Dist Hosp, Affiliated Hosp 1, Xian 710100, Shanxi, Peoples R China
[3] Shenzhen Customs Dist Port Outpatient Clin, Shenzhen Int Travel Hlth Care Ctr, Shenzhen 518033, Peoples R China
来源：
DISEASE MARKERS | 2021年 / 2021卷
关键词：
D O I：
10.1155/2021/3037337
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Ovarian cancer is one of the most lethal gynecologic malignancies for women. Due to the lack of efficient target therapy, the overall survival rate for patients with advanced ovarian cancer is still low. Illustrating the molecular mechanisms dictating ovarian cancer progression is critically important to develop novel therapeutic agents. Here, we found that RNA-binding motif protein 11 (RBM11) was highly elevated in ovarian cancer tissues compared with normal ovary, while RBM11 depletion in ovarian cancer cells resulted in impaired cell growth and invasion. Moreover, knockdown of RBM11 also retarded tumor growth in the A2780 ovarian cancer xenograft model. Mechanically, we found that RBM11 positively regulated Akt/mTOR signaling pathway activation in ovarian cancer cells. Thus, these results identify RBM11 is a novel oncogenic protein and prognostic biomarker for ovarian cancers.
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页数：7
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