Synthesis and Regiospecific Bromination of (2E,4E)-5-Aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitrile

被引：6

作者：

Pakholka, N. A. ^{[1
]}

Dotsenko, V. V. ^{[2
,3
]}

Krivokolysko, B. S. ^{[4
]}

Frolov, K. A. ^{[1
,4
]}

Aksenov, N. A. ^{[3
]}

Aksenova, I. V. ^{[3
]}

Shcherbakov, S. V. ^{[3
]}

Ovcharov, S. N. ^{[3
]}

Krivokolysko, S. G. ^{[1
,4
]}

机构：

[1] V Dahl Lugansk State Univ, Lab KhimEx, UA-91034 Lugansk, Ukraine

[2] Kuban State Univ, Krasnodar 350040, Russia

[3] North Caucasus Fed Univ, Stavropol 355009, Russia

[4] St Luke Lugansk State Med Univ, UA-91045 Lugansk, Ukraine

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 04期

关键词：

cyanothioacetamide; Knoevenagel condensation; (2E; 4E)-5-aryl-2-cyano-2; 4-pentadienethioamides; Hantzsch thiazole synthesis; bromination; 5-bromothiazoles; RADZISZEWSKI OXIDATION; MOLECULAR DOCKING; DERIVATIVES; THIAZOLE; (E)-3-ARYL-2-(THIAZOL-2-YL)ACRYLONITRILES; CYANOTHIOACETAMIDE; DESIGN;

D O I：

10.1134/S1070363221040058

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of (2E,4E)-5-phenyl-2-cyano-2,4-pentadienethioamide or (E)-3-(2-nitrophenyl)acrolein and cyanothioacetamide with alpha-bromoketones afforded new (2E,4E)-5-aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitriles. Direct bromination of the latter by the action of bromine in DMF proceeded regiospecifically at the C-5 position of the thiazole ring without affecting the diene system and leads to the formation of new series of (2E,4E)-5-aryl-2-(5-bromo-4-arylthiazol-2-yl)penta-2,4-dienenitriles.

引用

页码：606 / 613

页数：8

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