Monodisperse chitosan nanoparticles for mucosal drug delivery

被引：217
|
作者：
Zhang, H
Oh, M
Allen, C
Kumacheva, E
机构：
[1] Univ Toronto, Dept Pharmaceut Sci, Toronto, ON M5S 2S2, Canada
[2] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
BIOMACROMOLECULES | 2004年 / 5卷 / 06期
关键词：
D O I：
10.1021/bm0496211
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chitosan nanoparticles (CS NPs) of a controlled size (below 100 nm) and narrow size distribution were obtained through the process of ionic gelation between CS and sodium tripolyphosphate (TPP). A high degree of CS deacetylation and narrow polymer molecular weight distribution were demonstrated to be critical for the controlling particle size distribution. Properties of the CS NPs were examined at different temperatures, values of pH, and ratios of CS to TPP. The model protein, bovine serum albumin, was encapsulated into the NPs, and the in vitro release profiles were examined in physiologically relevant media at 37 degreesC.
引用
收藏
页码：2461 / 2468
页数：8
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