High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux

被引：111
|
作者：
Chuanchuen, R [1 ]
Karkhoff-Schweizer, RR [1 ]
Schweizer, HP [1 ]
机构：
[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Coll Vet Med & Biomed Sci, Ft Collins, CO 80523 USA
来源：
AMERICAN JOURNAL OF INFECTION CONTROL | 2003年 / 31卷 / 02期
关键词：
D O I：
10.1067/mic.2003.11
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 mug/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 mug/mL is solely attributable to the expression of efflux pumps.
引用
收藏
页码：124 / 127
页数：4
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