High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux

被引：111
|
作者：
Chuanchuen, R [1 ]
Karkhoff-Schweizer, RR [1 ]
Schweizer, HP [1 ]
机构：
[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Coll Vet Med & Biomed Sci, Ft Collins, CO 80523 USA
来源：
AMERICAN JOURNAL OF INFECTION CONTROL | 2003年 / 31卷 / 02期
关键词：
D O I：
10.1067/mic.2003.11
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 mug/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 mug/mL is solely attributable to the expression of efflux pumps.
引用
收藏
页码：124 / 127
页数：4
相关论文
共 50 条
  • [1] HIGH-LEVEL QUINOLONE RESISTANCE IN PSEUDOMONAS-AERUGINOSA
    PIDDOCK, LJV
    PANCHAL, S
    INGLIS, TJJ
    HAWKEY, PM
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1992, 30 (02) : 229 - 231
  • [2] Contributions of efflux pumps to high level resistance of Pseudomonas aeruginosa to ciprofloxacin
    WANG Dandan SUN Tieying HU Yunjian Department of Graduate SchoolChinese Academy of Medical Sciences Peking Union Medical CollegeBeijing China Wang DDDepartment of Pulmonary MedicineBeijing HospitalBeijing China Sun TYDepartment of MicrobiologyBeijing HospitalBeijing China Hu YJ
    [J]. ChineseMedicalJournal., 2007, 120 (01) - 70
  • [3] Contributions of efflux pumps to high level resistance of Pseudomonas aeruginosa to ciprofloxacin
    Wang Dan-dan
    Sun Tie-ying
    Hu Yun-jian
    [J]. CHINESE MEDICAL JOURNAL, 2007, 120 (01) : 68 - 70
  • [4] Contributions of efflux pumps to high level resistance of Pseudomonas aeruginosa to ciprofloxacin
    WANG Dan-dan SUN Tie-ying HU Yun-jian Department of Graduate School
    [J]. 中华医学杂志(英文版), 2007, (01) : 68 - 70
  • [5] High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations
    Chalhoub, Hussein
    Saenz, Yolanda
    Rodriguez-Villalobos, Hector
    Denis, Olivier
    Kahl, Barbara C.
    Tulkens, Paul M.
    Van Bambeke, Francoise
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2016, 48 (06) : 740 - 743
  • [6] The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan
    Chuanchuen, R
    Narasaki, CT
    Schweizer, HP
    [J]. JOURNAL OF BACTERIOLOGY, 2002, 184 (18) : 5036 - 5044
  • [7] High-level tolerance to triclosan may play a role in Pseudomonas aeruginosa antibiotic resistance in immunocompromised hosts: Evidence from outbreak investigation
    D'Arezzo S.
    Lanini S.
    Puro V.
    Ippolito G.
    Visca P.
    [J]. BMC Research Notes, 5 (1)
  • [8] Molecular Epidemiology and Mechanisms of High-Level Resistance to Meropenem and Imipenem in Pseudomonas aeruginosa
    Hassuna, Noha Anwar
    Darwish, Marwa K.
    Sayed, Mohamed
    Ibrahem, Reham Ali
    [J]. INFECTION AND DRUG RESISTANCE, 2020, 13 : 285 - 293
  • [9] High-level fluoroquinolone resistance in Pseudomonas aeruginosa due to interplay of the MexAB-OprM efflux pump and the DNA gyrase mutation
    Nakajima, A
    Sugimoto, Y
    Yoneyama, H
    Nakae, T
    [J]. MICROBIOLOGY AND IMMUNOLOGY, 2002, 46 (06) : 391 - 395
  • [10] High-level amikacin resistance in Pseudomonas aeruginosa associated with a 3′-phosphotransferase with high affinity for amikacin
    Torres, C
    Perlin, MH
    Baquero, F
    Lerner, DL
    Lerner, SA
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 15 (04) : 257 - 263
12345