Improving the Armamentarium of PI3K Inhibitors with Isoform-Selective Agents: A new Light in the Darkness

被引：24
|
作者：
Rodon, Jordi [1 ]
Tabernero, Josep [2 ,3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Invest Canc Therapeut, Houston, TX 77030 USA
[2] Vall Hebron Univ Hosp, Med Oncol Dept, Barcelona, Spain
[3] VHIO, Barcelona, Spain
来源：
CANCER DISCOVERY | 2017年 / 7卷 / 07期
关键词：
RESISTANCE; CANCER;
D O I：
10.1158/2159-8290.CD-17-0500
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Excitement and drug-development efforts aimed at targetable genetic aberrations in the PI3K/AKT/mTOR pathway have declined due to the limited clinical performance of these inhibitors as monotherapies. New, more isoform-selective treatments, such as taselisib, promise to both expand the therapeutic window and increase efficacy. (C) 2017 AACR.
引用
收藏
页码：666 / 669
页数：4
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