Protective Role of the Apigenin against Tinidazole Induced Genotoxic Damage in Cultured Human Lymphocytes

被引：0
|
作者：
Hasan, Siddique Yasir [1 ]
Mohammad, Afzal [1 ]
机构：
[1] Aligarh Muslim Univ, Dept Zool, Human Genet & Toxicol Lab, Genet Sect, Aligarh 202002, Uttar Pradesh, India
来源：
RESEARCH JOURNAL OF BIOTECHNOLOGY | 2010年 / 5卷 / 02期
关键词：
Apigenin; Tinidazole; Human lymphocytes; NORDIHYDROGUAIARETIC ACID NDGA; L; EXTRACT;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Tinidazole has been reported mutagenic in various test systems, besides having anti-protozoal properties. In the present study the effect of apigenin was studied against the genotoxic doses tinidazole using chromosomal aberrations and sister chromatid exchanges as a parameter in cultured human peripheral blood lymphocytes. A significant dose dependent decrease in chromosomal aberration and sister chromatid exchange was observed when the tinidazole genotoxic doses treatments were given along with the non-genotoxic doses of apigenin. The results suggest a protective role of apigenin against the tinidazole genotoxic doses.
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页码：29 / 32
页数：4
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