A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

被引：6

作者：

Cheruvallath, ZS ^{[1
]}

Cole, DL ^{[1
]}

Ravikumar, VT ^{[1
]}

机构：

[1] ISIS Pharmaceut, Carlsbad, CA 92008 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(02)00922-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new reagent immobilized on solid support allowing for solid-phase synthesis of oligonucleotides with a 3'-terminal phosphorothioate monoester is described. The support is compatible with phosphoramidite chemistry for automated oligonucleotide synthesis. Final deprotection with ammonia under standard conditions leads to oligonucleotide 3'-terminal phosphorothioate. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：281 / 284

页数：4

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