A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

被引：6
|
作者：
Cheruvallath, ZS [1 ]
Cole, DL [1 ]
Ravikumar, VT [1 ]
机构：
[1] ISIS Pharmaceut, Carlsbad, CA 92008 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0960-894X(02)00922-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new reagent immobilized on solid support allowing for solid-phase synthesis of oligonucleotides with a 3'-terminal phosphorothioate monoester is described. The support is compatible with phosphoramidite chemistry for automated oligonucleotide synthesis. Final deprotection with ammonia under standard conditions leads to oligonucleotide 3'-terminal phosphorothioate. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：281 / 284
页数：4
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