Impact of the matrix metalloproteinase MMP-3 on dementia

被引：20
|
作者：
Helbecque, Nicole
Cottel, Dominique
Hermant, Xavier
Amouyel, Philippe
机构：
[1] Inst Pasteur Lille 1, INSERM, U744, F-59019 Lille, France
[2] Univ Lille 2, CHRU Lille, Lille, France
来源：
NEUROBIOLOGY OF AGING | 2007年 / 28卷 / 08期
关键词：
Alzheimer's disease; late-onset Alzheimer's disease; beta-amyloid peptide; clearance; matrix metalloproteinase; genetic polymorphism; genetic association study;
D O I：
10.1016/j.neurobiolaging.2006.05.030
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Cerebral accumulation of P-amyloid peptide (A beta) is a central event in the pathogenesis of Alzheimer's disease (AD). Several proteases were shown to hydrolyze A beta in vitro or in cell-based assays, and are likely candidates for a role in A beta clearance in brain. Previous reports suggest that matrix metalloproteinases (MMPs) could be involved in such a mechanism. A functional polymorphism at position - 1171 (5A/6A) in MMP-3 was examined in two independent studies to investigate the impact of this polymorphism on the risk of developing dementia. We found that subjects APOE epsilon 4 non-carriers and 6A/6A homozygous for the MMP-3 polymorphism were at increased risk of dementia. Our findings support the hypothesis that MMPs may influence the risk of dementia. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1215 / 1220
页数：6
相关论文
共 50 条
  • [21] Roles for tumor-derived matrix metalloproteinase 3 (MMP-3) in prostate cancer growth in bone
    Frieling, J. S.
    Cook, L. M.
    Tauro, M.
    Lynch, C. C.
    CLINICAL & EXPERIMENTAL METASTASIS, 2019, 36 (02) : 157 - 157
  • [22] THE DIAGNOSTIC USEFULNESS OF DETERMINATION OF MATRIX METALLOPROTEINASE 3 (MMP-3) IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT (MCI)
    Muszynski, P.
    Groblewska, M.
    Mroczko, B.
    Zboch, M.
    Kulczynska-Przybik, A.
    Baranski, D.
    Mor, A.
    Szmitkowski, M.
    Kornhuber, J.
    Lewczuk, P.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 36 : 250 - 251
  • [23] Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and -3 serum concentration and associates with breast cancer
    Sahar Balkhi
    Farhad Mashayekhi
    Ali Salehzadeh
    Hamid Saeedi Saedi
    Molecular Biology Reports, 2020, 47 : 9637 - 9644
  • [24] Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation
    Nuebling, G.
    Levin, J.
    Bader, B.
    Israel, L.
    Boetzel, K.
    Lorenzl, S.
    Giese, A.
    EXPERIMENTAL NEUROLOGY, 2012, 237 (02) : 470 - 476
  • [25] Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease
    Okamoto, K
    Mimura, K
    Murawaki, Y
    Yuasa, I
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2005, 20 (07) : 1102 - 1108
  • [26] Prediction of Antiarthritic Drug Efficacies by Monitoring Active Matrix Metalloproteinase-3 (MMP-3) Levels in Collagen-Induced Arthritic Mice Using the MMP-3 Probe
    Lee, Aeju
    Park, Kyeongsoon
    Choi, Sung-Jae
    Seo, Dong-Hyun
    Kim, Kwangmeyung
    Kim, Han Sung
    Choi, Kuiwon
    Kwon, Ick Chan
    Yoon, Soo-Young
    Youn, Inchan
    MOLECULAR PHARMACEUTICS, 2014, 11 (05) : 1450 - 1458
  • [27] Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and-3 serum concentration and associates with breast cancer
    Balkhi, Sahar
    Mashayekhi, Farhad
    Salehzadeh, Ali
    Saedi, Hamid Saeedi
    MOLECULAR BIOLOGY REPORTS, 2020, 47 (12) : 9637 - 9644
  • [28] Matrix Metalloproteinase-3 (MMP-3) Is an Endogenous Activator of the MMP-9 Secreted by Placental Leukocytes: Implication in Human Labor
    Flores-Pliego, Arturo
    Espejel-Nunez, Aurora
    Castillo-Castrejon, Marisol
    Meraz-Cruz, Noemi
    Beltran-Montoya, Jorge
    Zaga-Clavellina, Veronica
    Nava-Salazar, Sonia
    Sanchez-Martinez, Maribel
    Vadillo-Ortega, Felipe
    Estrada-Gutierrez, Guadalupe
    PLOS ONE, 2015, 10 (12):
  • [29] Characterizing the role of matrix metalloproteinase-3 (MMP-3) in the pathogenesis of acute respiratory distress syndrome (ARDS)
    Meneses, Axel
    Beke, Keriann
    Correll, Kelly
    Foster, Daniel
    Downey, Gregory
    Radisky, Derek
    Radisky, Evette
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 300 (03) : S242 - S242
  • [30] Serum matrix metalloproteinase-3 (MMP-3) a valid predictor of disease progression in early ankylosing spondylitis
    Abou-Raya, A.
    Abou-Raya, S.
    Helmii, M.
    ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 : 385 - 386
12345