Study on the effects of grape seed extract in ehrlich ascitic carcinoma

被引：0
|
作者：
Adriana, Muresan [1 ]
Suciu, Soimita [1 ]
Clichici, Simona [1 ]
Daicoviciu, Doina [1 ]
Pop, Nastasia [2 ]
Potescu, I. D. [3 ]
机构：
[1] Univ Med & Pharm, Cluj Napoca, Romania
[2] Univ Agr Sci & Vet Med, Cluj Napoca, Romania
[3] I Chiricuta Oncol Inst, Cluj Napoca, Romania
来源：
BULLETIN OF THE UNIVERSITY OF AGRICULTURAL SCIENCES AND VETERINARY MEDICINE, VOL 63, 2006: VETERINARY MEDICINE | 2006年 / 63卷
关键词：
oxidative stress; grape seed extract; doxorubicin; Ehrlich ascitic carcinoma;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The seed extract (GSE) of Burgund Mare de Recas grape variety was evaluated for antitumor activity against Ehrlich ascites carcinoma(EAC)-bearing Swiss albino mice. The antioxidant activity of GSE was also estimated in EAC-bearing mice treated with doxorubicin 2x0.1 mg/mouse. The composition in polyphenols of the GSE, expressed as gallic acid, consisted of 11.477mg/l. The anti-tumor activity of GSE was assessed by measuring the tumor volume and by counting the tumor cells. As oxidative stress parameters the total thiobarbituric reactive reactive substances (TBARS) in the plasma were measured. The results indicate that GSE does not dot possess antitumor activity against Ehrlich ascitic carcinoma cells, does not interfere with the antitumor effects of doxorubicin in EAC-bearing mice and decreases the lipid peroxidation induced by doxorubicin treatment. http://journals.usamvcluj.ro/index.php/veterinary/article/view/2438/2416
引用
收藏
页码：114 / +
页数：3
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