Magnetic polymer enhanced hybrid capsules prepared from a novel Pickering emulsion polymerization and their application in controlled drug release

Magnetic polymer enhanced hybrid capsules (MPEHCs) were successfully prepared from a novel Pickering emulsion polymerization. The resultant products were characterized by Transmission electron microscopy (TEM), Scanning electron microscopy (SEM), Fourier transform infrared spectrum (FTIR), Thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS) and Vibration sample magnetometer (VSM). It was proved that the MPEHCs consist of SiO2 outer shell and magnetic polymer inner shell with particle sizes from 0.8 mu m to 2 mu m and thickness about 140 nm. The MPEHCs were applied as a drug carrier to study their controlled release behaviors and ibuprofen was used as a model drug. The curve of release behaviors of ibuprofen exhibited a typical sustained release pattern, indicating that the MPEHCs could be applied as a promising drug vehicle for controlled release systems. (C) 2009 Elsevier B. V. All rights reserved.