The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis

被引：8
|
作者：
Long, Jianting [1 ]
Fang, Shi [2 ]
Dai, Qiangsheng [1 ]
Liu, Xiaolian [3 ]
Zhu, Wanshou [3 ]
Wang, Shenming [4 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Oncol, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Nutr, Guangzhou 510080, Guangdong, Peoples R China
[3] Gaozhou Peoples Hosp, Dept Hematol, Gaozhou 525200, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Vasc Surg, Guangzhou 510080, Guangdong, Peoples R China
来源：
ONCOTARGET | 2016年 / 7卷 / 22期
基金：
中国国家自然科学基金; 国家教育部博士点专项基金资助;
关键词：
acute myeloid leukemia; Wilms' tumor gene 1; association; meta-analysis; SINGLE-NUCLEOTIDE POLYMORPHISM; EXPRESSION; GENE; DIFFERENTIATION; PREDICTS; CANCER;
D O I：
10.18632/oncotarget.8117
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although a number of studies suggested that WT1 rs16754 polymorphism might be related to decreased relapse free survival (RFS) and overall survival (OS). The results remain controversial. Published reports were searched in PubMed, EMBASE, and Google Scholar. Twelve publications with 3903 patients had met the inclusion criteria and were subjected to further examination. We found WT1 rs16754 polymorphism was significantly associated with OS in AML (OR = 0.62; 95% CI 0.52 - 0.75; p < 0.00001; I-2 = 47%). WT1 rs16754 polymorphism was also significantly associated with RFS in AML (OR = 0.69; 95% CI 0.57 - 0.83; p < 0.001; I-2 = 46%). In the subgroup analyses of age, race, and subtype of AML, WT1 rs16754 polymorphism was a independent favorable-risk marker. In conclusion, WT1 rs16754 polymorphism is associated with better survival of AML. It could be used as a cost-effective prognostic biomarker for AML.
引用
收藏
页码：32079 / 32087
页数：9
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