Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

被引：452
|
作者：
Kim, Hongtae
Chen, Junjie
Yu, Xiaochun
机构：
[1] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06520 USA
[2] Univ Michigan, Sch Med, Dept Internal Med, Div Med & Mol Genet, Ann Arbor, MI 48109 USA
来源：
SCIENCE | 2007年 / 316卷 / 5828期
关键词：
D O I：
10.1126/science.1139621
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of breast and ovarian cancers. BRCA1 participates in the cellular DNA damage response. We report the identification of receptor-associated protein 80 (RAP80) as a BRCA1-interacting protein in humans. RAP80 contains a tandem ubiquitin-interacting motif domain, which is required for its binding with ubiquitin in vitro and its damage-induced foci formation in vivo. Moreover, RAP80 specifically recruits BRCA1 to DNA damage sites and functions with BRCA1 in G(2)/M checkpoint control. Together, these results suggest the existence of a ubiquitination-dependent signaling pathway involved in the DNA damage response.
引用
收藏
页码：1202 / 1205
页数：4
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