Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

被引：911

作者：

Li, Xingshu ^{[1
]}

Kwon, Nahyun ^{[1
]}

Guo, Tian ^{[1
]}

Liu, Zhuang ^{[2
]}

Yoon, Juyoung ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

[2] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 36期

基金：

中国国家自然科学基金; 新加坡国家研究基金会;

关键词：

hypoxia; oxygen delivery; photodynamic therapy; tumors; PHOTOTHERMAL THERAPY; HYDROGEN-PEROXIDE; OXYGEN CARRIERS; SINGLET OXYGEN; LIGHT DELIVERY; GOLD NANORODS; CANCER; NANOPARTICLES; PHOTOSENSITIZER; HYALURONAN;

D O I：

10.1002/anie.201805138

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.

引用

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页码：11522 / 11531

页数：10

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