Effects of retrograde gastric electrical stimulation with pulse trains on gastric emptying of solids and plasma hormones in dogs

被引：12
|
作者：
Song, Geng-Qing
Hou, Xiaohua
Sun, Yan
Yang, Bin
Qian, Wei
Chen, Eande D. Z.
机构：
[1] Univ Texas, Med Branch, Div Gastroenterol, GI Res, Galveston, TX 77555 USA
[2] Huazhong Univ Sci & Technol, Union Hosp, Div Gastroenterol, Tongji Med Coll, Wuhan 430074, Peoples R China
来源：
AMERICAN JOURNAL OF SURGERY | 2007年 / 194卷 / 01期
关键词：
gastric electrical stimulation; gastric pacing; gastric emptying; satiety hormones;
D O I：
10.1016/j.amjsurg.2006.12.036
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: Retrograde gastric electrical stimulation (RGES) is proposed as a novel therapy for obesity. However, mechanisms of RGES are not fully investigated. The aim of this study was to investigate the effects of RGES with trains of pulses on gastric slow waves, gastric emptying of solids, and plasma concentrations of satiety-related peptides and glucose. Methods: Seven female beagle dogs implanted with 4 pairs of gastric electrodes on the gastric serosa were studied (control and RGES). Gastric emptying, gastric slow waves, and signs were recorded in each session. Plasma leptin, insulin, glucagons, and glucose were also measured. Results: RGES with pulse trains (a pulse width of 2 milliseconds) significantly decreased gastric emptying of solids and plasma insulin but has no effect on plasma leptin, glucagons, and glucose. Conclusion: Acute gastric electrical stimulation with pulse trains is able to decrease gastric emptying of solids and plasma insulin but has no effects on plasma leptin, glucagons, and glucose. (c) 2007 Excerpta Medica Inc. All rights reserved.
引用
收藏
页码：122 / 127
页数：6
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