Synthesis and crystal structure of 4-(2-chlorophenyl)-5-cyano-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydropyrazolo[3,4-b] pyridine under microwave irradiation

被引：0

作者：

Zhu, SL

Tu, SJ ^{[1
]}

Li, TJ

Zou, X

Zhang, XJ

Ji, SJ

Zhang, Y

机构：

[1] Xuzhou Normal Univ, Dept Chem, Key Lab Biotechnol Med Plant, Xuzhou 221116, Jiangsu, Peoples R China

[2] Xuzhou Med Coll, Dept Chem, Xuzhou 221002, Jiangsu, Peoples R China

[3] Suzhou Univ, Coll Chem & Chem Engn, Key Lab Org Synth, Suzhou 215006, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2004年 / 23卷 / 11期

关键词：

aminopyrazole; pyrazolopyridine; crystal structure; microwave irradiation;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title compound (C20H15ClN4O, M-r = 362.81) was synthesized by the reaction of ethyl 2-cyano-3-(2-chlorophenyl)-1-acylate with 5-amino-3-methyl-1-phenylpyrazole under microwave irradiation and its structure was determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P2(1)/n with a = 8.8192(19), b = 15.976(3), c = 13.094(3) Angstrom, beta = 103.074(4)degrees, V = 1797.1(7) Angstrom(3), Z = 4, D-c = 1.341 g/cm(3), mu = 0.229 mm(-1), F(000) = 752, R = 0.0632 and wR = 0.1278. X-ray analysis reveals that the pyridine ring adopts an envelope conformation. The dihedral angle between the pyrazole and pyridine planes is 2.19degrees, and intermolecular hydrogen bonds are also observed in the molecule.

引用

页码：1222 / 1225

页数：4

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