Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

被引：8
|
作者：
Qi, Hao [1 ]
Li, Xin [1 ]
Liu, Zhuang [1 ]
Miao, Shan-Shan [1 ]
Fang, Zheng [1 ]
Chen, Lin [1 ]
Fang, Zheng [1 ]
Guo, Kai [1 ,2 ]
机构：
[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China
[2] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Jiangsu, Peoples R China
来源：
CHEMISTRYSELECT | 2018年 / 3卷 / 38期
基金：
中国国家自然科学基金;
关键词：
C2; heterocycle; Halogenation; Microreactor; Nucleophilic substitution; Selectfluor; HETEROCYCLIC N-OXIDES; SILVER(I) COMPLEXES; MICRO-REACTION; FUNCTIONALIZATION; MICROREACTOR; TECHNOLOGY; DYNAMICS;
D O I：
10.1002/slct.201802925
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel green and efficient reaction route for the synthesis of 2-chloroquinoline via N-fluoride fluorinated by 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo [2.2.2] octane bis(tetrafluoroborate) (Selectfluor) with 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) in Vapourtec reactor has been developed. In addition, a series of C2 heterocyclic derivative products are obtained in moderate to good yields under no metal conditions.
引用
收藏
页码：10689 / 10693
页数：5
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