Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor

被引：8

作者：

Qi, Hao ^{[1
]}

Li, Xin ^{[1
]}

Liu, Zhuang ^{[1
]}

Miao, Shan-Shan ^{[1
]}

Fang, Zheng ^{[1
]}

Chen, Lin ^{[1
]}

Fang, Zheng ^{[1
]}

Guo, Kai ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Jiangsu, Peoples R China

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 38期

基金：

中国国家自然科学基金;

关键词：

C2; heterocycle; Halogenation; Microreactor; Nucleophilic substitution; Selectfluor; HETEROCYCLIC N-OXIDES; SILVER(I) COMPLEXES; MICRO-REACTION; FUNCTIONALIZATION; MICROREACTOR; TECHNOLOGY; DYNAMICS;

D O I：

10.1002/slct.201802925

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel green and efficient reaction route for the synthesis of 2-chloroquinoline via N-fluoride fluorinated by 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo [2.2.2] octane bis(tetrafluoroborate) (Selectfluor) with 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) in Vapourtec reactor has been developed. In addition, a series of C2 heterocyclic derivative products are obtained in moderate to good yields under no metal conditions.

引用

页码：10689 / 10693

页数：5

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