Carbohydrate derivatives for use in drug design:: Cyclic αv-selective RGD peptides

被引：0
|
作者：
Lohof, E
Planker, E
Mang, C
Burkhart, F
Dechantsreiter, MA
Haubner, R
Wester, HJ
Schwaiger, M
Hölzemann, G
Goodman, SL
Kessler, H
机构：
[1] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Garching, Germany
[2] Klinikum Rechts Isar, Nukl Med Klin & Poliklin, D-81675 Munich, Germany
[3] Merck KGAA, D-64271 Darmstadt, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 15期
关键词：
D O I：
10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.
引用
收藏
页码：2761 / 2764
页数：4
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