Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo

被引：87

作者：

Ulges, Alexander ^{[1
]}

Klein, Matthias ^{[1
]}

Reuter, Sebastian ^{[2
]}

Gerlitzki, Bastian ^{[1
]}

Hoffmann, Markus ^{[1
]}

Grebe, Nadine ^{[1
]}

Staudt, Valerie ^{[1
]}

Stergiou, Natascha ^{[1
]}

Bohn, Toszka ^{[1
]}

Bruehl, Till-Julius ^{[1
]}

Muth, Sabine ^{[1
]}

Yurugi, Hajime ^{[1
]}

Rajalingam, Krishnaraj ^{[1
]}

Bellinghausen, Iris ^{[3
]}

Tuettenberg, Andrea ^{[3
]}

Hahn, Susanne ^{[3
]}

Reissig, Sonja ^{[4
]}

Haben, Irma ^{[5
]}

Zipp, Frauke ^{[6
]}

Waisman, Ari ^{[4
]}

Probst, Hans-Christian ^{[1
]}

Beilhack, Andreas ^{[7
]}

Buchou, Thierry ^{[8
]}

Filhol-Cochet, Odile ^{[9
]}

Boldyreff, Brigitte ^{[10
]}

Breloer, Minka ^{[5
]}

Jonuleit, Helmut ^{[3
]}

Schild, Hansjoerg

Schmitt, Edgar ^{[1
]}

Bopp, Tobias ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Immunol, Univ Med Ctr, Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Med Clin 3, Dept Pulm Med, D-55122 Mainz, Germany

[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, D-55122 Mainz, Germany

[4] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, D-55122 Mainz, Germany

[5] Bernhard Nocht Inst Trop Med, Dept Virol & Immunol, D-20359 Hamburg, Germany

[6] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Neurol, D-55122 Mainz, Germany

[7] Univ Wurzburg, Zentrum Expt Mol Med, Expt Stammzelltransplantat Med Klin & Poliklin 2, D-97070 Wurzburg, Germany

[8] Univ Grenoble 1, Fac Med, Inst Albert Boniot, INSERM,U823, La Tronche, France

[9] Commissariat Energie Atom & Enerigies Alternat, Inst Rech Technol & Sci Vivant Biol Canc & Infect, INSERM, U1036, Grenoble, France

[10] KinaseDetect, Aarslev, Denmark

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 03期

关键词：

TRANSCRIPTION FACTOR IRF4; DENDRITIC CELLS; EXPRESSION; WNT; TOLERANCE; DISRUPTION; INHIBITORS; INDUCTION; PROMOTE; SHP-1;

D O I：

10.1038/ni.3083

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The quality of the adaptive immune response depends on the differentiation of distinct CD4(+) helper T cell subsets, and the magnitude of an immune response is controlled by CD4(+)Foxp3(+) regulatory T cells (T-reg cells). However, how a tissue- and cell type-specific suppressor program of T-reg cells is mechanistically orchestrated has remained largely unexplored. Through the use of T-reg cell-specific gene targeting, we found that the suppression of allergic immune responses in the lungs mediated by T helper type 2 (T(H)2) cells was dependent on the activity of the protein kinase CK2. Genetic ablation of the beta-subunit of CK2 specifically in Treg cells resulted in the proliferation of a hitherto-unexplored ILT3(+) T-reg cell subpopulation that was unable to control the maturation of IRF4(+)PD-L2(+) dendritic cells required for the development of T(H)2 responses in vivo.

引用

下载

页码：267 / U227

页数：12

共 50 条

[21] Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity
Odile Filhol
Sofia Giacosa
Yann Wallez
Claude Cochet
Cellular and Molecular Life Sciences, 2015, 72 : 3305 - 3322
[22] Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin
Kulartz, M
Hiller, E
Kappes, F
Pinna, LA
Knippers, R
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 315 (04) : 1011 - 1017
[23] Protein kinase CK2:: evidence for a protein kinase CK2β subunit fraction, devoid of the catalytic CK2α subunit, in mouse brain and testicles
Guerra, B
Siemer, S
Boldyreff, B
Issinger, OG
FEBS LETTERS, 1999, 462 (03) : 353 - 357
[24] Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity
Filhol, Odile
Giacosa, Sofia
Wallez, Yann
Cochet, Claude
CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (17) : 3305 - 3322
[25] Protein Kinase CK2 and Angiogenesis
Montenarh, Mathias
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2014, 23 (02): : 153 - 158
[26] Interaction between CK2α and CK2β, the Subunits of Protein Kinase CK2: Thermodynamic Contributions of Key Residues on the CK2α Surface
Raaf, Jennifer
Bischoff, Nils
Klopffleisch, Karsten
Brunstein, Elena
Olsen, Birgitte B.
Vilk, Greg
Litchfield, David W.
Issinger, Olaf-Georg
Niefind, Karsten
BIOCHEMISTRY, 2011, 50 (04) : 512 - 522
[27] Protein Kinase CK2 in Health and DiseaseProtein kinase CK2: From structures to insights
K. Niefind
J. Raaf
O.-G. Issinger
Cellular and Molecular Life Sciences, 2009, 66 : 1800 - 1816
[28] Ecto-protein kinase CK2, the neglected form of CK2
Montenarh, Mathias
Goetz, Claudia
BIOMEDICAL REPORTS, 2018, 8 (04) : 307 - 313
[29] In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) β-subunit
Jauch, E
Melzig, J
Brkulj, M
Raabe, T
GENE, 2002, 298 (01) : 29 - 39
[30] ROLE OF THE PROTEIN KINASE CK2 IN THE BIOLOGY OF CHOLANGIOCARCINOMA CELLS
Di Maira, G.
Gentilini, A.
Rovida, E.
Ottaviani, D.
Ruzzene, M.
Marra, F.
DIGESTIVE AND LIVER DISEASE, 2016, 48 : E20 - E20

← 1 2 3 4 5 →