Variants in multi-gene polymorphism association analysis of lung cancer in the Chinese Han population

Lung cancer (LC) is a common malignant tumor that is influenced by an interaction between genetic and environmental factors. Until now, the inherited factors of lung cancer have not been clear. Our study selected 16 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with lung cancer in the Han population. In this Han Chinese case-control study, we genotyped 554 cases and 696 controls using Sequenom MassARRAY technology and analyzed their associations with the cancer using chi(2) test, SNPStats software, and Microsoft Excel. Based on chi(2) tests, RBMS3-rs1530057 (P=0.05), TP63-rs4488809, rs10937405 (P=0.013, P=0.014), VTI1A-rs7086803 (P=0.03) and RAD52-rs10849605 (P=0.008) correlate with lung cancer risk. In the genetic model analyses, increased risk for lung cancer was associated with the genotypes "TT" in rs4488809 (OR=1.38, 95% CI, 1.03-1.86; P=0.033) in the recessive model and under the log-additive model (OR=1.2, 95% CI=1.00-1.43, P=0.046). Also, our analysis revealed the genotype "C/C" in rs10849605 was associated with increased risk of lung cancer under the codominant model (OR=1.71, 95% CI=1.13-2.58, P=0.039), the recessive model (OR=1.62, 95% CI=1.10-2.39, P=0.015), and under the log-additive model (P=0.021, OR=1.25, 95% CI=1.03-1.50). We found four genes (RBMS3, TP63, VTI1A and RAD52) are associated with lung cancer susceptibility. In combination with previous reports, our results suggest that these genes may be associated with lung cancer in the Han population.