Variants in multi-gene polymorphism association analysis of lung cancer in the Chinese Han population

被引:0
|
作者
Zhang, Yong [1 ]
Yang, Xiaomei [2 ]
You, Jiangtao [1 ]
Li, Shuo [1 ]
Duan, Mengling [3 ]
Li, Haijun [1 ]
He, Haiqi [1 ]
Chen, Nanzheng [1 ]
Jin, Tianbo [4 ,5 ]
Fu, Junke [1 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Thorac Surg, 96 277 West Yanta Rd, Xian 710061, Peoples R China
[2] Chinas Ordnance Ind Grp, Hosp 521, Xian 710065, Shannxi Provinc, Peoples R China
[3] Peoples Hosp Hainan Prov, Dept Emergency, Haikou 570102, Peoples R China
[4] Natl Engn Res Ctr Miniaturized Detect Syst, Xian 710069, Peoples R China
[5] NW Univ Xian, Sch Life Sci, Xian 710069, Shaanxi, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 03期
关键词
Lung cancer; tag single nucleotide polymorphism (tSNP); case-control study; SYNTHETICALLY LETHAL; RAD52; INACTIVATION; CELL; EXPRESSION; VTI1A; CARCINOMA; MUTATION; BINDING; BRCA2; P63;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Lung cancer (LC) is a common malignant tumor that is influenced by an interaction between genetic and environmental factors. Until now, the inherited factors of lung cancer have not been clear. Our study selected 16 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with lung cancer in the Han population. In this Han Chinese case-control study, we genotyped 554 cases and 696 controls using Sequenom MassARRAY technology and analyzed their associations with the cancer using chi(2) test, SNPStats software, and Microsoft Excel. Based on chi(2) tests, RBMS3-rs1530057 (P=0.05), TP63-rs4488809, rs10937405 (P=0.013, P=0.014), VTI1A-rs7086803 (P=0.03) and RAD52-rs10849605 (P=0.008) correlate with lung cancer risk. In the genetic model analyses, increased risk for lung cancer was associated with the genotypes "TT" in rs4488809 (OR=1.38, 95% CI, 1.03-1.86; P=0.033) in the recessive model and under the log-additive model (OR=1.2, 95% CI=1.00-1.43, P=0.046). Also, our analysis revealed the genotype "C/C" in rs10849605 was associated with increased risk of lung cancer under the codominant model (OR=1.71, 95% CI=1.13-2.58, P=0.039), the recessive model (OR=1.62, 95% CI=1.10-2.39, P=0.015), and under the log-additive model (P=0.021, OR=1.25, 95% CI=1.03-1.50). We found four genes (RBMS3, TP63, VTI1A and RAD52) are associated with lung cancer susceptibility. In combination with previous reports, our results suggest that these genes may be associated with lung cancer in the Han population.
引用
收藏
页码:6807 / 6812
页数:6
相关论文
共 50 条
  • [1] Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population
    Zhou, C. -P.
    Pan, H. -Z.
    Li, F. -X
    Hu, N. -Y.
    Li, M.
    Yang, X. -X.
    GENETICS AND MOLECULAR RESEARCH, 2014, 13 (02) : 3673 - 3680
  • [2] Association Between GSDMB Gene Polymorphism and Cervical Cancer in the Northeast Chinese Han Population
    Li, Songxue
    Li, Xiaoying
    Zhang, Shuang
    Feng, Yanan
    Jia, Tianshuang
    Zhu, Manning
    Fang, Lei
    Gong, Liping
    Dong, Shuang
    Kong, Xianchao
    Wang, Zhenzhen
    Sun, Litao
    FRONTIERS IN GENETICS, 2022, 13
  • [3] Association of hTERT Gene Polymorphism and Colorectal Cancer (CRC) Risk in the Chinese Han Population
    Fu, Xianxian
    Xiong, Yanyan
    Tang, Renjin
    Li, Xuelin
    Liu, Hong
    Ren, Xiaowei
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2024, 263 (02): : 89 - 95
  • [4] Association between MTHFR gene polymorphism and NTDs in Chinese Han population
    Yu, Yang
    Wang, Fang
    Bao, Yihua
    Lu, Xiaolin
    Quan, Li
    Lu, Ping
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2014, 7 (09): : 2901 - 2906
  • [5] Association of CHUK gene polymorphism and ischemic stroke in the Han Chinese population
    Huang, Jingyan
    Wei, Qiugui
    Liang, Baoyun
    Shen, Tingting
    Wu, Yanli
    Chen, Ziwen
    Yang, Junwei
    Gu, Lian
    JOURNAL OF CLINICAL NEUROSCIENCE, 2021, 88 : 271 - 276
  • [6] Association study of AGER gene polymorphism and hypertension in Han Chinese population
    Yang, Song
    Wang, Hairu
    Yang, Yichun
    Wang, Wen
    Jiang, Jiandong
    Zhao, Xianghai
    Du, Qinglian
    Wang, Xuecai
    Yao, Yingshui
    Shen, Hongbing
    Shen, Chong
    Zhao, Yanping
    GENE, 2012, 498 (02) : 311 - 316
  • [7] Association study of CRP gene polymorphism and hypertension in Han Chinese population
    Zhao, Yanping
    Wang, Hairu
    Liu, Sijun
    Zhao, Xianghai
    Chen, Yanchun
    Yang, Yichun
    Wang, Wen
    Wu, Yiming
    Chen, Aiqin
    Tang, Junming
    Yao, Yingshui
    Li, Yun
    Chen, Jinfeng
    Shen, Chong
    Yang, Song
    GENE, 2013, 512 (01) : 41 - 46
  • [8] Association of BDNF Gene Polymorphism with Bipolar Disorders in Han Chinese Population
    Wang, Z.
    Li, Z.
    Chen, J.
    Huang, J.
    Yuan, C.
    Hong, W.
    Yu, S.
    Fang, Y.
    GENES BRAIN AND BEHAVIOR, 2012, 11 (05) : 524 - 528
  • [9] Association between GLS Gene Polymorphisms and the Susceptibility to Lung Cancer in the Chinese Han Population
    Wang, Yuhe
    Chen, Mingyue
    Yi, Faling
    Xu, Jinpeng
    Liu, Changchun
    Zhang, Ziyi
    Wang, Ping
    Jin, Tianbo
    Chen, Mingwei
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2023, 28 (05):
  • [10] Association of the Polymorphism of APE1 Gene with the Risk of Prostate Cancer in Chinese Han Population
    Jing, Bao
    Wang, Juan
    Chang, Wen-Liang
    Li, Bo
    Chen, Jing
    Niu, Yuan-Jie
    CLINICAL LABORATORY, 2013, 59 (1-2) : 163 - 168