Green synthesis of silver nanoparticles having specific anticancer activity against MDA-MB 468 carcinoma cells

被引：6
|
作者：
Siddiqui, Nurunnesa [1 ]
Pal, Kunal [2 ]
Mohammad, Mukti [3 ]
Karmakar, Parimal [2 ]
Maidul Islam, Md [3 ]
Mukhopadhyay, Subrata [1 ]
机构：
[1] Jadavpur Univ, Dept Chem, Kolkata 700032, India
[2] Jadavpur Univ, Dept Life Sci & Biotechnol, Kolkata 700032, India
[3] Aliah Univ, Dept Chem, Kolkata 700156, India
来源：
ADVANCES IN NATURAL SCIENCES-NANOSCIENCE AND NANOTECHNOLOGY | 2021年 / 12卷 / 02期
关键词：
cytotoxicity study; anticancer activity; Protein binding; Punica granatum; nanomedicine; LEAF EXTRACT; POMEGRANATE JUICE; STRUCTURAL-CHARACTERIZATION; DYE DEGRADATION; CANCER-THERAPY; DRUG-DELIVERY; IN-VIVO; ANTIBACTERIAL; GLYCOL; SHAPE;
D O I：
10.1088/2043-6262/abffc8
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this work formation of silver nanoparticles using pomegranate fruit (Punica granatum) extract and its bio applications were studied. Gradual appearance of a peak at 422 nm during the reduction of AgNO3 by the fruit extract confirmed the formation of AgNPs. FTIR spectra indicated the details of formation mechanism. Images obtained from scanning electron microscopy (SEM) and transmittance electron microscopy (TEM) confirmed that the sample contains spherical AgNPs and XRD analysis showed its (FCC) crystal structure. This study also revealed that the synthesised AgNPs were monocrystalline in nature. Application of these AgNPs were studied measuring their affinity to bovine serum albumin (BSA) and human serum albumin (HSA). Cytotoxicity of the synthesised AgNPs was determined by DAPI staining. The results showed that the nanoparticles have significant anticancer activity against triple negative breast carcinoma and MDA-MB-468 cells. We concluded that the cell death was routed through apoptotic pathway.
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页数：8
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