Cross-species comparisons of host genetic associations with the microbiome

被引：198

作者：

Goodrich, Julia K. ^{[1
]}

Davenport, Emily R. ^{[1
]}

Waters, Jillian L. ^{[1
,3
]}

Clark, Andrew G. ^{[1
]}

Ley, Ruth E. ^{[1
,2
,3
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY USA

[2] Cornell Univ, Dept Microbiol, Ithaca, NY USA

[3] Max Planck Inst Dev Biol, Dept Microbiome Sci, Tubingen, Germany

来源：

SCIENCE | 2016年 / 352卷 / 6285期

基金：

美国国家科学基金会;

关键词：

GUT MICROBIOME; GENOME; DIET; DIVERSITY; NUTRITION; SHAPE;

D O I：

10.1126/science.aad9379

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies in human populations and mouse models reveal notable congruences in gut microbial taxa whose abundances are partly regulated by host genotype. Host genes associating with these taxa are related to diet sensing, metabolism, and immunity. These broad patterns are further validated in similar studies of nonmammalian microbiomes. The next generation of genome-wide association studies will expand the size of the data sets and refine the microbial phenotypes to fully capture these intriguing signatures of host-microbiome coevolution.

引用

页码：532 / 535

页数：4

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