Convenient procedures for synthesis of ciproxifan, a histamine H3-receptor antagonist

被引：0
|
作者：
Stark, H [1 ]
机构：
[1] Free Univ Berlin, Inst Pharm, D-14195 Berlin, Germany
来源：
ARCHIV DER PHARMAZIE | 2000年 / 333卷 / 09期
关键词：
cyclopropanes; etherifications; Mitsunobu reactions; histamine H-3 receptors; antagonists;
D O I：
10.1002/1521-4184(20009)333:9<315::AID-ARDP315>3.0.CO;2-M
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cyclopropyl 9-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone (ciproxifan) is a novel reference antagonist for the histamine H-3 receptor. Despite the former Mitsunobu reaction the actual key reaction for preparation based on SNAr for acylated fluoroaromatics with an additional cyclization in a one-pot procedure needs no chromatographic purification steps and results in good yields.
引用
收藏
页码：315 / 316
页数：2
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