Adaptive Multi-scaled Simulation Algorithm for Biochemical Reaction in Complex Systems

被引：0
|
作者：
Turner, Jesse [1 ]
Ji, Lin [2 ,3 ]
Cox, Dennis [2 ]
机构：
[1] Rice Univ, Dept Computat & Appl Math, Houston, TX 77251 USA
[2] Rice Univ, Dept Stat, Houston, TX 77251 USA
[3] Capital Normal Univ, Dept Chem, Beijing, Peoples R China
来源：
2011 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE WORKSHOPS | 2011年
关键词：
STOCHASTIC SIMULATION; CHEMICAL-KINETICS;
D O I：
暂无
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
A new hybrid simulation method is introduced that adaptively combines the four most efficient simulation methods at different scales by dynamically partitioning the reactions according to both the reaction propensity and the molecular abundance. Simulation results prove it to be accurate but much more efficient than SSA. This could provide an accurate and efficient multiscale solution for biochemical reaction simulations in systems biology, since it covers more scales efficiently and can be easily updated by "plugging-in" the latest algorithm in a specified level.
引用
收藏
页码：925 / 927
页数：3
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