Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis

被引：31
|
作者：
Garay, Laura [1 ,2 ]
Gonzalez Deniselle, Maria Claudia [1 ,3 ]
Sitruk-Ware, Regine [4 ]
Guennoun, Rachida [5 ]
Schumacher, Michael [5 ]
De Nicola, Alejandro F. [1 ,2 ]
机构：
[1] Inst Biol & Med Expt, Lab Neuroendocrine Biochem, RA-1428 Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Med, Dept Human Biochem, RA-1053 Buenos Aires, DF, Argentina
[3] Univ Buenos Aires, Fac Med, Dept Physiol, RA-1053 Buenos Aires, DF, Argentina
[4] Rockefeller Univ, Populat Council, New York, NY 10021 USA
[5] Univ Paris Sud, UMR Inserm 788, Le Kremlin Bicetre, France
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 276卷 / 1-2期
关键词：
Experimental autoimmune encephalomyelitis; Nestorone; Microglia; Behavior; ADULT HIPPOCAMPAL NEUROGENESIS; MULTIPLE-SCLEROSIS; INFLAMMATION ALTERS; CELL-PROLIFERATION; DENTATE GYRUS; BRAIN-INJURY; SPINAL-CORD; MOUSE MODEL; MALE-MICE; NEUROPROTECTION;
D O I：
10.1016/j.jneuroim.2014.08.619
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1 + microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：89 / 97
页数：9
相关论文
共 50 条
  • [41] Neurofilament phosphoform changes in chronic experimental autoimmune encephalomyelitis model
    Cioni, C.
    De Santi, L.
    Cantalupo, L.
    Berti, G.
    Malandrini, A.
    Annunziata, P.
    MULTIPLE SCLEROSIS, 2006, 12 : S52 - S52
  • [42] Fumarate therapy ameloriates chronic experimental autoimmune encephalomyelitis (EAE).
    Schilling, S
    Goelz, S
    Linker, RA
    Luhder, F
    Gold, R
    CLINICAL IMMUNOLOGY, 2005, 115 : S88 - S88
  • [43] Clozapine Regulates Microglia and Is Effective in Chronic Experimental Autoimmune Encephalomyelitis
    Ceylan, Ulas
    Haupeltshofer, Steffen
    Kaemper, Laura
    Dann, Justus
    Ambrosius, Bjorn
    Gold, Ralf
    Faissner, Simon
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [44] Prolactin Is Not Required for the Development of Severe Chronic Experimental Autoimmune Encephalomyelitis
    Costanza, Massimo
    Musio, Silvia
    Abou-Hamdan, Mhamad
    Binart, Nadine
    Pedotti, Rosetta
    JOURNAL OF IMMUNOLOGY, 2013, 191 (05): : 2082 - 2088
  • [45] A CB2 Receptor Agonist Reduces the Production of Inflammatory Mediators and Improves Locomotor Activity in Experimental Autoimmune Encephalomyelitis
    Parastouei, Karim
    Aarabi, Mohammad Hossein
    Hamidi, Gholam Ali
    Nasehi, Zahra
    Kabiri-Arani, Shima
    Jozi, Faezeh
    Shahaboddin, Mohammad Esmaeil
    REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2022, 11 (01): : 1 - 9
  • [46] Cinnabarinic Acid, an Endogenous Agonist of type-4 Metabotropic Glutamate Receptor, Suppresses Experimental Autoimmune Encephalomyelitis in Mice
    Fazio, F.
    Zappulla, C.
    Notartomaso, S.
    Busceti, C.
    Bessede, A.
    Scarselli, P.
    Vacca, C.
    Gargaro, M.
    Allegrucci, M.
    Lionetto, L.
    Simmaco, M.
    Belladonna, M. L.
    Nicoletti, F.
    Fallarino, F.
    CURRENT NEUROPHARMACOLOGY, 2014, 12 : 18 - 18
  • [47] Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model
    Ni, X
    Gu, YJ
    Geller, EB
    Eisenstein, TK
    Adler, MW
    Tuma, RF
    FASEB JOURNAL, 2003, 17 (04): : A68 - A68
  • [48] Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice
    Fazio, Francesco
    Zappulla, Cristina
    Notartomaso, Serena
    Busceti, Carla
    Bessede, Alban
    Scarselli, Pamela
    Vacca, Carmine
    Gargaro, Marco
    Volpi, Claudia
    Allegrucci, Massimo
    Lionetto, Luana
    Simmaco, Maurizio
    Belladonna, Maria Laura
    Nicoletti, Ferdinando
    Fallarino, Francesca
    NEUROPHARMACOLOGY, 2014, 81 : 237 - 243
  • [49] Treatment with the Retinoid X Receptor Agonist IRX4204 Ameliorates Active and Passive Experimental Autoimmune Encephalomyelitis in Mice
    Nowak, Elizabeth
    Chandraratna, Rosh
    Noelle, Randolph
    NEUROLOGY, 2016, 86
  • [50] Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model
    Ni, X
    Geller, EB
    Eppihimer, MJ
    Eisenstein, TK
    Adler, MW
    Tuma, RF
    MULTIPLE SCLEROSIS JOURNAL, 2004, 10 (02) : 158 - 164
12345