Expression of antimicrobial peptides has an antitumour effect in human cells

被引:95
|
作者
Winder, D [1 ]
Günzburg, WH
Erfle, V
Salmons, B
机构
[1] Bavarian Nord Res Inst, D-80807 Munich, Germany
[2] GSF, Natl Res Ctr Environm & Hlth, D-85764 Oberschleissheim, Germany
[3] Univ Vet Sci, Inst Virol, A-1210 Vienna, Austria
关键词
D O I
10.1006/bbrc.1997.8014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The antimicrobial peptides cecropin and melittin are known to exhibit antitumour activity in tumour derived cell lines. To achieve a similar effect in vivo these peptides would have to be given repeatedly to maintain therapeutic levels, which may be pharmacologically unfavourable. The expression of the genes encoding such antimicrobial peptides in the desired cell type may circumvent these problems. Expression constructs carrying cecropin or melittin have been introduced into a human bladder carcinoma derived cell line and the resultant cell clones analysed for tumorigenicity in nude mice. Expression of cecropin resulted in either a complete loss of tumorigenicity in some clones or reduced tumorigenicity, as measured by latency of tumour formation. These results suggest that vector mediated delivery of this gene to tumour cells may prove useful for cancer gene therapy. (C) 1998 Academic Press.
引用
收藏
页码:608 / 612
页数:5
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